Please use this identifier to cite or link to this item: http://www.repositorio.cdtn.br:8080/jspui/handle/123456789/433
Title: Production of the radioactive antitumoral cisplatin
Title of periodic: Applied Radiation and Isotopes
Authors: Leal, Alexandre Soares
Carvalho Júnior, Álvaro D.
Abrantes, Fabiana M.
Menezes, Maria Ângela de Barros Correia
Ferraz, Vany
Cruz, Tamara S.
Cardoso, Valbert N.
Oliveira, Mônica C. de
Affiliation: Centro de Desenvolvimento da Tecnologia Nuclear/CDTN, Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil
Centro de Desenvolvimento da Tecnologia Nuclear/CDTN, Belo Horizonte, MG, Brasil; Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil
Centro de Desenvolvimento da Tecnologia Nuclear/CDTN, Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil
Issue Date: 2006
Keywords: Platinum complexes;labelled compounds;TRIGA-Brazil reactor
Abstract: This work presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDDP, sealed in a cadmium capsule. The irradiation of CDDP covered by cadmium, employing exposure times longer than 2 h, demonstrated good chemical purity and high specific activity. This finding allowed a better detection of in vivo CDDP and suggest that it may be a good tool for studies of long-term biodistribution of pharmaceutical formulations containing this drug.
Access: L
Appears in Collections:Artigo de periódico

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