Use of labelled cisplatin obtained by direct irradiation in a preliminary biodistribution study

Abstract

This paper presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDP, from its direct irradiation into a cadmium capsule, using TRIGA Mark I IPR R-1 research reactor of the CDTN. The ability to detect CDDP in Ehrlich tumour-bearing mice after administration via an intravenous route was evaluated. After 24 hours, blood and some organs were collected to determine the incorporated activity. The CDDP showed a great chemical purity and high specific activity that resulted in an optimum in vivo detection. The CDDP was taken up principally by liver, spleen and kidney. The CDDP obtained from this condition was shown to be a good tool for biodistribution studies.