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http://www.repositorio.cdtn.br:8080/jspui/handle/123456789/417| Title: | Immunization with radioattenuated yeast cells of Paracoccidioides brasiliensis induces a long lasting protection in BALB/c mice |
| Title of periodic: | Vaccine Kidlinton |
| Authors: | Martins, Estefânia Mara do Nascimento Reis, Bernardo Sgarbi Fernandes, Viviane Cristina Costa, Míriam Maria Silva Goes, Alfredo Miranda Andrade, Antero Silva Ribeiro de |
| Affiliation: | Centro de Desenvolvimento da Tecnologia Nucler/CDTN, Belo Horizonte, MG, Brasil Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil Centro de Desenvolvimento da Tecnologia Nuclear/CDTN, Belo Horizonte, MG, Brasil |
| Issue Date: | 2007 |
| Keywords: | Fungi;vaccines;gamma radiation |
| Abstract: | Paracoccidioides brasiliensis is the fungus agent of paracoccidioidomycosis, a chronic systemic disease prevalent in Latin America. The aim of the present work was to evaluate the protection elicited by the immunization of BALB/c mice with radioattenuated yeast cells of P. brasiliensis. The immunization promoted a long lasting protection against highly infective yeast forms of P. brasiliensis. A 99.5 percent decrease in CFUs recovery was verified 90 days post challenge. At the same time the levels of IgG2a and IFN-gamma were high while a very low production of IL-10 and IL-5 was verified, suggesting that a Th1 pattern was dominant. This work shows the potential of radioattenuated yeast cells for thedevelopment of vaccines against fungi infections |
| Access: | L |
| Appears in Collections: | Artigo de periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Art-01_Estefania_MNMartins.pdf | 1.62 MB | Adobe PDF | View/Open |
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